Article
PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome.
Nucleic acids research - 1 Jan 2014
Girardot Michael, Hirasawa Ryutaro, Kacem Salim, Fritsch Lauriane, Pontis Julien, Kota Satya K, Filipponi Doria, Fabbrizio Eric, Sardet Claude, Lohmann Felix, Kadam Shilpa, Ait-Si-Ali Slimane, Feil Robert
Abstract excerpt
Symmetrical dimethylation on arginine-3 of histone H4 (H4R3me2s) has been reported to occur at several repressed genes, but its specific regulation and genomic distribution remained unclear. Here, we show that the type-II protein arginine methyltransferase PRMT5 controls H4R3me2s in mouse embryon...
Topics
- Alleles
- Animals
- Arginine
- Cells, Cultured
- Chromatin
- DNA Methylation
- Fibroblasts
- GC Rich Sequence
- Genome
- Genomic Imprinting
- Histones
- Methylation
- Mice
- Promoter Regions, Genetic