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Article

PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome.

Nucleic acids research - 1 Jan 2014

Girardot Michael, Hirasawa Ryutaro, Kacem Salim, Fritsch Lauriane, Pontis Julien, Kota Satya K, Filipponi Doria, Fabbrizio Eric, Sardet Claude, Lohmann Felix, Kadam Shilpa, Ait-Si-Ali Slimane, Feil Robert

Abstract excerpt

Symmetrical dimethylation on arginine-3 of histone H4 (H4R3me2s) has been reported to occur at several repressed genes, but its specific regulation and genomic distribution remained unclear. Here, we show that the type-II protein arginine methyltransferase PRMT5 controls H4R3me2s in mouse embryonic fibroblasts (MEFs). In these differentiated cells, we find that the genome-wide pattern of H4R3me2s is highly...

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Identifiers

PMID: 24097435
DOI: 10.1093/nar/gkt884
PMCID: PMC3874197

Genes

PRMT5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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