Article

Uncovering a role for METTL13 in malignant transformation of human hematopoietic stem cells and in the progression of pediatric leukemia

2025-10-23

Abstract excerpt

<title>Abstract</title> Post-transcriptional RNA modifications, such as N6-methyladenosine (m6A) methylation and adenosine to inosine (A-to-I) editing, are critical regulators of hematopoietic stem cell (HSC) self-renewal and differentiation, yet their precise contributions to malignant transformation are not fully elucidated. In this study, we uncovered the epitranscriptomic landscape caused by knockdown of g...

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Literature Corpus work: a82374eb-3284-5644-996a-80d087876fe9
DOI: 10.21203/rs.3.rs-7652169/v1

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