Article

Broad misappropriation of developmental splicing profile by cancer in multiple organs

2021-12-15

Abstract excerpt

Oncogenesis mimics key aspects of embryonic development. However, the underlying molecular determinants are not completely understood. Leveraging temporal transcriptomic data during development in multiple human organs, we demonstrate that the ‘embryonic positive (EP)’ alternative splicing events, specifically active during human organogenesis, are broadly reactivated in the organ-specific tumor. EP events are ass...

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Literature Corpus work: 3e2263ab-ddf4-5216-9b80-b3c3ff580a32
DOI: 10.1101/2021.12.13.472504

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