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Benchmarking PRS methods for risk prediction of 36 complex traits in UK Biobank by establishment of a large-scale PRS computation platform PRS-hub

2025-03-18

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<title>Abstract</title> <p>Polygenic risk score (PRS) provides a personalized measure of genetic contribution to complex traits, spurring the development of numerous methods for its estimation. Currently, there are no widely comparative studies that are sufficiently tailored to externally benchmark the efficacy of various methods, nor are there standardized platforms for efficient, large-scale PRS computation. To...

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Literature Corpus work: c453f81b-08e7-5c57-98b1-38fb15306888
DOI: 10.21203/rs.3.rs-6158628/v1

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