Article

Significant Sparse Polygenic Risk Scores across 813 traits in UK Biobank

2021-09-06

Abstract excerpt

We present a systematic assessment of polygenic risk score (PRS) prediction across more than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse PRS models with significant (p < 2.5 × 10 −5 ) incremental predictive performance when compared against the covariate-only model that considers age, sex, types of genotyping arrays, and the principal component loadings of genotypes. We re...

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Literature Corpus work: 8ac20db7-c18a-5235-99a2-75b8738ba306
DOI: 10.1101/2021.09.02.21262942

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