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Polygenic risk score portability for common diseases across genetically diverse populations.

Human genomics - 2 Sept 2024

Moreno-Grau Sonia, Vernekar Manvi, Lopez-Pineda Arturo, Mas-Montserrat Daniel, Barrabés Míriam, Quinto-Cortés Consuelo D, Moatamed Babak, Lee Ming Ta Michael, Yu Zhenning, Numakura Kensuke, Matsuda Yuta, Wall Jeffrey D, Ioannidis Alexander G, Katsanis Nicholas, Takano Tomohiro, Bustamante Carlos D

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS) derived from European individuals have reduced portability across global populations, limiting their clinical implementation at worldwide scale. Here, we investigate the performance of a wide range of PRS models across four ancestry groups (Africans, Europeans, East Asians, and South Asians) for 14 conditions of high-medical interest. METHODS: To select the best-performing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39218908
DOI: 10.1186/s40246-024-00664-y
PMCID: PMC11367857

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