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Article

BridgePRS leverages shared genetic effects across ancestries to increase polygenic risk score portability.

Nature genetics - 1 Jan 2024

Hoggart Clive J, Choi Shing Wan, García-González Judit, Souaiaia Tade, Preuss Michael, O'Reilly Paul F

Abstract excerpt

Here we present BridgePRS, a novel Bayesian polygenic risk score (PRS) method that leverages shared genetic effects across ancestries to increase PRS portability. We evaluate BridgePRS via simulations and real UK Biobank data across 19 traits in individuals of African, South Asian and East Asian ancestry, using both UK Biobank and Biobank Japan genome-wide association study summary statistics; out-of-cohort...

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Identifiers

PMID: 38123642
DOI: 10.1038/s41588-023-01583-9
PMCID: PMC10786716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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