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Advancements and limitations in polygenic risk score methods for genomic prediction: a scoping review.

Human genetics - 1 Dec 2024

Jayasinghe Dovini, Eshetie Setegn, Beckmann Kerri, Benyamin Beben, Lee S Hong

Abstract excerpt

This scoping review aims to identify and evaluate the landscape of Polygenic Risk Score (PRS)-based methods for genomic prediction from 2013 to 2023, highlighting their advancements, key concepts, and existing gaps in knowledge, research, and technology. Over the past decade, various PRS-based methods have emerged, each employing different statistical frameworks aimed at enhancing prediction accuracy, processing...

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PMID: 39542907
DOI: 10.1007/s00439-024-02716-8

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