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Article

Significant sparse polygenic risk scores across 813 traits in UK Biobank.

PLoS genetics - 1 Mar 2022

Tanigawa Yosuke, Qian Junyang, Venkataraman Guhan, Justesen Johanne Marie, Li Ruilin, Tibshirani Robert, Hastie Trevor, Rivas Manuel A

Abstract excerpt

We present a systematic assessment of polygenic risk score (PRS) prediction across more than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse PRS models with significant (p < 2.5 x 10-5) incremental predictive performance when compared against the covariate-only model that considers age, sex, types of genotyping arrays, and the principal component loadings of genotypes. We...

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Identifiers

PMID: 35324888
DOI: 10.1371/journal.pgen.1010105
PMCID: PMC8946745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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