Article

Polygenic risk score portability for common diseases across genetically diverse populations

2024-06-14

Abstract excerpt

<h4>Background</h4> Polygenic risk scores (PRS) derived from European individuals have reduced portability across global populations, limiting their clinical implementation at worldwide scale. Here, we investigate the performance of a wide range of PRS models across four ancestry groups (Africans, Europeans, East Asians, and South Asians) for 14 conditions of high-medical interest. <h4>Methods</h4> To select the b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9cf6305-cb02-5fd8-beba-7cbde1fda349
DOI: 10.1101/2024.06.13.24308905

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk score portability for common diseases across genetically diverse populationsDOI 10.1101/2024.06.13.24308905Read

Polygenic risk score portability for common diseases across genetically diverse populations.Semantic proximity Read

Optimization of Multi-Ancestry Polygenic Risk Score Disease Prediction ModelsSemantic proximity Read

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseasesSemantic proximity Read

BridgePRS leverages shared genetic effects across ancestries to increase polygenic risk score portability.Semantic proximity Read

Bridging traditional risk factors and genetic insights: A review on polygenic risk scores in cardiovascular diseasesSemantic proximity Read

Benchmarking PRS methods for risk prediction of 36 complex traits in UK Biobank by establishment of a large-scale PRS computation platform PRS-hubSemantic proximity Read

Leveraging pleiotropy to improve genetic risk prediction across diseasesSemantic proximity Read

A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variants.Semantic proximity Read

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseasesSemantic proximity Read

Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.Semantic proximity Read

Assessment of polygenic risk score performance in East Asian populations for ten common diseasesSemantic proximity Read

Performance of Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the All of Us Program.Semantic proximity Read