Article

Astrocyte-secreted glypican-4 drives APOE4-dependent tau pathology

2021-07-09

Abstract excerpt

<h4>ABSTRACT</h4> The aggregation of tau proteins into insoluble filaments and the spread of these filaments across brain regions are the major drivers of neurodegeneration in tauopathies, including in Alzheimer’s disease (AD). Apolipoprotein E4 ( APOE4 ), a crucial genetic risk factor for late-onset AD, has been shown to exacerbate tau pathology in mouse models. However, the exact mechanisms through which APOE4...

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Literature Corpus work: c39eea32-1c19-5ad4-8b0e-57cf7c03b75e
DOI: 10.1101/2021.07.07.451493

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