Article

Properties of Alzheimer’s disease brain-derived tau aggregates define tau processing by human astrocytes

2024-09-05

Abstract excerpt

<h4>Summary</h4> The templated misfolding of tau proteins accounts for tau pathology spread in Alzheimer’s disease (AD). Post-translational modifications, including phosphorylation at specific residues, are closely linked with tau seeding ability and clinical disease progression. Increasing evidence supports a contributing role for astrocytes in tau spread. This study demonstrates that tau aggregates from postmor...

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Literature Corpus work: f2b43f0f-0206-5247-838c-efc38f3b48ed
DOI: 10.1101/2024.09.04.610753

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