Article

<i>APOE3</i> - <i>R136S</i> mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition

2024-04-28

Abstract excerpt

<h4>Summary</h4> The Christchurch mutation (R136S) on the APOE3 ( E3 S/S ) gene is associated with attenuation of tau load and cognitive decline despite the presence of a causal PSEN1 mutation and high levels of amyloid beta pathology in the carrier 1 . However, the specific molecular mechanisms enabling the E3 S/S mutation to mitigate tau-induced neurodegeneration remain unclear. Here, we replaced mouse...

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Literature Corpus work: 9e4ff2a3-1839-5355-b00f-ee7da9869f0d
DOI: 10.1101/2024.04.25.591140

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