Article

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model

2025-02-09

Abstract excerpt

<h4>Summary</h4> The pathological hallmarks of neurodegeneration are the aberrant post-translational modification and aggregation of proteins. Genetic factors, like APOE4, increase the prevalence and severity of tau, amyloid, and α-synuclein pathologies. However, the human brain is largely inaccessible during this process, limiting mechanistic understanding. Here, we developed an iPSC-based 3D model that integra...

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Literature Corpus work: e057aad2-8e26-592e-a994-4d685e49f7f8
DOI: 10.1101/2025.02.09.637107

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Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue ModelDOI 10.1101/2025.02.09.637107Read

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