Article

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function

2023-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Due to the importance of 4R tau in the pathogenicity of primary tauopathies, it has been challenging to model these diseases in iPSC-derived neurons, which express very low levels of 4R tau. To address this problem we have developed a panel of isogenic iPSC lines carrying the MAPT splice-site mutations S305S, S305I or S305N, derived from four different donors. All three mutations significantly...

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Literature Corpus work: 2d4d47a8-0b7c-5a9c-8ba8-9d942e935ace
DOI: 10.1101/2023.06.02.543224

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