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Article

Engineered Alzheimer Organoids Validate the Link Between Intracellular and Soluble p-Tau Biomarkers and Highlight the Contribution of Astrocytic Tau.

Neuroscience bulletin - 1 Sept 2026

Zhang Ru, Dong Xiaoxu, Pei Gang, Huang Shichao

Abstract excerpt

Soluble phosphorylated tau has become a key biomarker for Alzheimer's disease pathology, yet further mechanistic studies are needed beyond observational investigations to clarify the relationship between soluble p-tau species and intracellular tau pathology. Here, we utilized chimeric human cerebral organoids (chCOs) to generate a series of organoids in which the endogenous MAPT gene was CRISPR/Cas9 edited in...

Read the complete abstract on PubMed

Topics

tau Proteins
Humans
Astrocytes
Alzheimer Disease
Biomarkers
Phosphorylation
Organoids

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neurons

Brain

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 41964788
DOI: 10.1007/s12264-026-01615-4
PMCID: PMC13545177

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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