Article

APOE3 astrocytes can rescue lipid abnormalities and dystrophic neurites of APOE4 human neurons

2025-10-24

Abstract excerpt

Lipid abnormalities are emerging as key pathogenic mechanisms in neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Lewy body dementia. Astrocytes in the brain provide APOE proteins and influence neuronal metabolism and health. Using live cell imaging and objective neurite imaging techniques, we show that following induction of cellular lipid (cholesterol and triglycerides) load by inhibiting the lyso...

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Literature Corpus work: dbc176aa-59ac-554b-ad48-7a549ec06930
DOI: 10.1101/2025.10.24.684364

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