Article

Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer’s disease mouse model

2025-11-29

Abstract excerpt

Apolipoprotein E4 (APOE4), the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), exacerbates tau tangles, amyloid plaques, neurodegeneration, and neuroinflammation—the pathological hallmarks of AD. While astrocytes are the primary producers of APOE in the CNS, neurons increase APOE expression under stress and aging. Prior work established that neuronal APOE4 is essential for AD pathogenesis, b...

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Literature Corpus work: 4c473259-cb09-5628-99f9-02f933915716
DOI: 10.1101/2025.11.25.690488

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