Article

Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer’s disease

2025-12-09

Abstract excerpt

Apolipoprotein E4 (APOE4) confers the greatest genetic risk for developing Alzheimer’s disease (AD). With APOE4 broadly expressed in the brain, its cell-type-specific roles in AD pathogenesis are only beginning to be defined. Here, we show that neuronal APOE4 expression drives damaging lipid accumulation in hippocampal neurons, oligodendrocytes, and microglia, with preferential buildup of peroxidized lipids in mic...

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Literature Corpus work: d7925ede-a022-527c-8be2-73cda3a8fc11
DOI: 10.64898/2025.12.04.692390

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