Article

Protective mechanisms against Alzheimer’s Disease in APOE3-Christchurch homozygous astrocytes

2025-01-21

Abstract excerpt

The APOE3-Christchurch (APOE3-Ch) variant has been linked to reduced Alzheimer’s Disease (AD) risk, but its protective mechanisms remain unclear. This study explores the neuroprotective phenotype of APOE3-Ch astrocytes, focusing on lipid metabolism and tau processing. APOE3-Ch astrocytes demonstrate enhanced tau oligomer uptake via HSPG- and LRP1-mediated pathways, facilitated by elevated HSPG expression, and achi...

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Literature Corpus work: 885a2a82-b99d-5fdd-83bf-bb5a742143bc
DOI: 10.1101/2025.01.21.634115

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