Back to search

Article

Neurotoxic astrocytes secreted glypican-4 drives Alzheimer’s tau pathology

2020-10-01

Abstract excerpt

<title>Abstract</title> <p>Apolipoprotein E4 (APOE4) is the most crucial genetic risk factor of late-onset Alzheimer’s disease (AD). However, the mechanism through which APOE4 induces AD risk remains unknown. Here, we report the astrocyte-secreted protein glypican-4 (GPC-4), as a novel binding partner of APOE4, drives tau pathology. APOE4-carrying AD patients display more tau accumulation compared to APOE4-noncar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
efd1ba45-b61f-515f-85a2-a8a0a3c261b0
DOI
10.21203/rs.3.rs-82205/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Neurotoxic astrocytes secreted glypican-4 drives Alzheimer’s tau pathologyDOI 10.21203/rs.3.rs-82205/v1
Astrocyte-secreted glypican-4 drives APOE4-dependent tau pathologySemantic proximity
Modeling Alzheimer’s Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic TargetsSemantic proximity
Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer’s disease mouse modelSemantic proximity
APOE4 is a Risk Factor and Potential Therapeutic Target for Alzheimer's DiseaseSemantic proximity
Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer’s diseaseSemantic proximity
The multifaceted roles of apolipoprotein E4 in Alzheimer’s disease pathology and potential therapeutic strategiesSemantic proximity
Astrocyte cell-surface proteomics identified CD44 as an OPN/SPP1 receptor regulating lipid metabolism and glial crosstalk in Alzheimer’s diseaseSemantic proximity
Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse modelsSemantic proximity
Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease.Semantic proximity
Protective mechanisms against Alzheimer’s Disease in APOE3-Christchurch homozygous astrocytesSemantic proximity
Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimer’s Disease Pathologies in NeuronsSemantic proximity
Properties of Alzheimer’s disease brain-derived tau aggregates define tau processing by human astrocytesSemantic proximity
Select a neighboring publication to make it the new centre.