Article

Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes

2024-02-01

Abstract excerpt

A major challenge in human genomics is to decipher the context specific relationship of sequence to function. However, existing tools for locus specific hypermutation and evolution in the native genome context are limited. Here we present a novel programmable platform for long-range, locus-specific hypermutation called helicase-assisted continuous editing (HACE). HACE leverages CRISPR-Cas9 to target a processive h...

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Literature Corpus work: c2a93e51-4758-5e1f-b20e-30d03ad46ed1
DOI: 10.1101/2024.02.01.577593

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