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Article

SNIPSNP: precision design of CRISPR/Cas9 knock-in reagents for variant correction and disease modeling.

Nucleic acids research - 11 Jul 2026

Labun Kornel, Rio Oline, Dahal-Koirala Shiva, Komisarczuk Anna Zofia, Valen Eivind, Haapaniemi Emma

Abstract excerpt

We present SNIPSNP (crisprtools.org/snipsnp), a comprehensive bioinformatics pipeline for designing experiments for CRISPR-induced homology-directed repair (HDR). The tool addresses the critical challenge of Cas9 re-cleavage by simplifying the selection of "blocking" silent variants that are effective at inhibiting RNP binding upon donor-templated editing. SNIPSNP handles complex edits, including indels, and uses...

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Identifiers

PMID: 42333535
DOI: 10.1093/nar/gkag409
PMCID: PMC13355073

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PAM

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