Article

Base editing screens map mutations affecting IFNγ signalling in cancer

2022-03-29

Abstract excerpt

IFNγsignalling underpins host responses to infection, inflammation and anti-tumour immunity. Mutations in the IFNγsignalling pathway cause immunological disorders, haematological malignancies, and resistance to immune checkpoint blockade (ICB) in cancer, however the function of most clinically observed variants remain unknown. Here, we systematically investigate the genetic determinants of IFNγresponse in colorect...

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Literature Corpus work: 1af61fc9-ea56-5a7f-8ba7-b4bb9d7488ee
DOI: 10.1101/2022.03.29.486051

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