Article

Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cells

2023-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Base editing enables generation of single nucleotide variants, but large-scale screening in primary human T cells is limited due to low editing efficiency, among other challenges 1 . Here, we developed a high-throughput approach for high-efficiency and massively parallel adenine and cytosine base-editor screening in primary human T cells. We performed multiple large-scale screens editing 102 ge...

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Literature Corpus work: 2988ef8e-c5cb-5d61-8fb7-083e07375541
DOI: 10.1101/2023.12.13.571465

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