Article

<i>In vivo</i> CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer

2022-03-13

Abstract excerpt

Functionally characterizing the genetic alterations that drive pancreatic cancer progression is a prerequisite for Precision Medicine. Here, we developed a somatic CRISPR/Cas9 mutagenesis screen to assess the transforming potential of 125 recurrently mutated ‘long-tail’ pancreatic cancer genes, which revealed USP15 and SCAF1 as novel and potent Pancreatic ductal adenocarcinoma PDAC tumor suppressors, with USP15 fu...

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Literature Corpus work: c14ece73-3e2e-5118-9b52-f8c40f98795f
DOI: 10.1101/2022.03.13.484174

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