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In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer

2022-12-22

Abstract excerpt

<title>Abstract</title> <p>Functionally characterizing the genetic alterations that drive pancreatic cancer is a prerequisite for precision medicine. Here, we performed somatic CRISPR/Cas9 mutagenesis screens to assess the transforming potential of 125 recurrently mutated pancreatic cancer genes, which revealed USP15 and SCAF1 as novel pancreatic tumor suppressors. Mechanistically, we found that USP15 functions i...

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Literature Corpus work
b46447ca-750b-5daf-bf5d-7db36241dcd8
DOI
10.21203/rs.3.rs-2352174/v1
Open publication

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In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancerDOI 10.21203/rs.3.rs-2352174/v1
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