Article

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug

2021-05-24

Abstract excerpt

<title>Abstract</title> <p>Background Pancreatic ductal adenocarcinoma (PDAC) remains an appallingly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as a novel cancer hallmark and attractive therapeutic target. The core splicing factor SF3B1 is heavily altered in cancer and can be inhibited by Pladienolide-B, but its actionability i...

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Literature Corpus work: dbb9a1a4-43a5-524a-89a8-71988642c46d
DOI: 10.21203/rs.3.rs-527836/v1

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