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The deubiquitinase USP10 protects pancreatic cancer cells from endoplasmic reticulum stress

21 Dec 2022

Abstract excerpt

The ubiquitin-specific peptidase 10 (USP10) plays a context-specific, pro or anti-tumorigenic role in different malignancies. However, the role of USP10 in pancreatic cancer remains unclear. Our protein and RNA level analysis from archived specimens and public databases show that USP10 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and expression correlates with poor overall patient survival....

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PMID: 36543867
DOI: 10.1038/s41698-022-00336-x

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