Back to search

Article

A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in <i>vivo</i> CRISPRCas9 mediated somatic recombination

2018-08-23

Abstract excerpt

<h4>ABSTRACT</h4> Genetically engineered mouse models (GEMMs) that recapitulate the major genetic drivers in pancreatic ductal adenocarcinoma (PDAC) have provided unprecedented insights into the pathogenesis of this lethal neoplasm. Nonetheless, generating an autochthonous model is an expensive, time consuming and labor intensive process, particularly when tissue specific expression or deletion of compound allele...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
33ea131b-2e8b-50a6-886b-275e529fc332
DOI
10.1101/398347
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in <i>vivo</i> CRISPRCas9 mediated somatic recombinationDOI 10.1101/398347
Genetic Mutations of Pancreatic Cancer and Genetically Engineered Mouse ModelsSemantic proximity
An <i>in vivo</i> KRAS allelic series reveals distinct phenotypes of common oncogenic variantsSemantic proximity
Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (<i>LSL‐Kras<sup>G12D/+</sup>;LSL‐Trp53<sup>R172H/+</sup>;Pdx‐1‐Cre</i>), Its Variants, and Their Application in Immuno‐oncology Drug DiscoverySemantic proximity
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.Semantic proximity
Differences between KC and KPC pancreatic ductal adenocarcinoma mice models, in terms of their modeling biology and their clinical relevance.Semantic proximity
Genetically engineered mouse models of pancreatic adenocarcinomaSemantic proximity
CRISPR/Cas technologies in pancreatic cancer research and therapeutics: recent advances and future outlookSemantic proximity
Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancerSemantic proximity
A prime editor mouse to model a broad spectrum of somatic mutations in vivo.Semantic proximity
Combinatorial tumor suppressor gene targeting immortalizes primary pancreatic ductal cells, resulting in temporal, deterministic structural patterns across the genomeSemantic proximity
Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncologySemantic proximity
Application of CRISPR for In Vivo Mouse Cancer StudiesSemantic proximity
Select a neighboring publication to make it the new centre.