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Article

Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.

Nature - 1 Apr 2024

Radko-Juettner Sandi, Yue Hong, Myers Jacquelyn A, Carter Raymond D, Robertson Alexis N, Mittal Priya, Zhu Zhexin, Hansen Baranda S, Donovan Katherine A, Hunkeler Moritz, Rosikiewicz Wojciech, Wu Zhiping, McReynolds Meghan G, Roy Burman Shourya S, Schmoker Anna M, Mageed Nada, Brown Scott A, Mobley Robert J, Partridge Janet F, Stewart Elizabeth A, Pruett-Miller Shondra M, Nabet Behnam, Peng Junmin, Gray Nathanael S, Fischer Eric S, Roberts Charles W M

Abstract excerpt

Whereas oncogenes can potentially be inhibited with small molecules, the loss of tumour suppressors is more common and is problematic because the tumour-suppressor proteins are no longer present to be targeted. Notable examples include SMARCB1-mutant cancers, which are highly lethal malignancies driven by the inactivation of a subunit of SWI/SNF (also known as BAF) chromatin-remodelling complexes. Here, to...

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Identifiers

PMID: 38538798
DOI: 10.1038/s41586-024-07250-1
PMCID: PMC11184678

Genes

SMARCB1
DCAF5
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.PMID 38538798Read ↗

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