Article

CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers

2023-04-17

Abstract excerpt

Somatic mutations are desirable targets for selective elimination of cancer, yet most are found within the noncoding regions. We propose a novel, cancer-specific killing approach using CRISPR-Cas9 which exploits the requirement of a protospacer adjacent motif (PAM) for Cas9 activity. Through whole genome sequencing (WGS) of paired tumor minus normal (T-N) samples from three pancreatic cancer patients (Panc480, Pan...

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Literature Corpus work: 3927a3fd-eafe-5582-b082-459ea581a5dd
DOI: 10.1101/2023.04.15.537042

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