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Article

In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer.

Nature communications - 20 Jun 2024

Martinez Sebastien, Wu Shifei, Geuenich Michael, Malik Ahmad, Weber Ramona, Woo Tristan, Zhang Amy, Jang Gun Ho, Dervovic Dzana, Al-Zahrani Khalid N, Tsai Ricky, Fodil Nassima, Gros Philippe, Gallinger Steven, Neely G Gregory, Notta Faiyaz, Sendoel Ataman, Campbell Kieran, Elling Ulrich, Schramek Daniel

Abstract excerpt

Functionally characterizing the genetic alterations that drive pancreatic cancer is a prerequisite for precision medicine. Here, we perform somatic CRISPR/Cas9 mutagenesis screens to assess the transforming potential of 125 recurrently mutated pancreatic cancer genes, which revealed USP15 and SCAF1 as pancreatic tumor suppressors. Mechanistically, we find that USP15 functions in a haploinsufficient manner and...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38902237
DOI: 10.1038/s41467-024-49450-3
PMCID: PMC11189927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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