Article

Direct and indirect regulation of β-glucocerebrosidase by the transcription factors <i>USF2</i> and <i>ONECUT2</i>

2024-04-28

Abstract excerpt

Mutations in the GBA gene, which encodes the lysosomal enzyme β-glucocerebrosidase (GCase), are the most prevalent genetic susceptibility factor for Parkinson’s disease (PD). However, only approximately 20% of carriers develop the disease, suggesting the presence of genetic modifiers influencing the risk of developing PD in the presence of GBA mutations. Here we screened 1,634 human transcription factors (TFs) f...

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Literature Corpus work: 34315b1f-ef76-56ff-9765-7f8c2085d707
DOI: 10.1101/2024.04.28.591482

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