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A CRISPR screen reveals a WNT7B-FZD5 signaling circuit as a therapeutic opportunity in pancreatic cancer

2016-03-01

Abstract excerpt

<h4>Abstract:</h4> CRISPR-Cas9 genome editing enables high-resolution detection of genetic vulnerabilities of cancer cells. We conducted a genome-wide CRISPR-Cas9 screen in RNF43 mutant pancreatic ductal adenocarcinoma (PDAC) cells, which rely on Wnt signaling for proliferation, and discovered a unique requirement for a WNT7B-FZD5 signaling circuit. Our results highlight an underappreciated level of functional s...

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Literature Corpus work
91b391ed-12de-5c9e-8c04-49a9e3cc94e7
DOI
10.1101/041996
Open publication

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