Article

VCP regulates early tau seed amplification via specific cofactors

2024-05-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to an adjacent or connected cell, and serves as a specific template for its own replication in the cytoplasm. In vitro seeding reactions typically take days, yet seeding into the complex cytoplasmic milieu happens...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c093d33d-6a67-58ff-afcd-fec474776a45
DOI: 10.21203/rs.3.rs-4307848/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

VCP regulates early tau seed amplification via specific cofactorsDOI 10.21203/rs.3.rs-4307848/v1Read

VCP regulates early tau seed amplification via specific cofactorsSemantic proximity Read

VCP increases or decreases tau seeding using specific cofactorsSemantic proximity Read

VCP protects neurons from proteopathic seedingSemantic proximity Read

VCP Protects Neurons from Proteopathic SeedingSemantic proximity Read

Tau seeds translocate across the cell membrane to initiate aggregationSemantic proximity Read

Human iPSC 4R tauopathy model uncovers modifiers of tau propagationSemantic proximity Read

Seeded aggregation of ANXA11 induces prion-like propagation, TDP-43 co-pathology and nucleocytoplasmic transport defectsSemantic proximity Read

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.Semantic proximity Read

Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s DiseaseSemantic proximity Read

VCP suppresses proteopathic seeding in neurons.Semantic proximity Read

Conformation-based detection of tau seeds with a novel VHHSemantic proximity Read

Selective Targeting of Pathogenic Tau Seeds via a Novel VHHSemantic proximity Read