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VCP regulates early tau seed amplification via specific cofactors

7 Jan 2025

Abstract excerpt

BACKGROUND: Neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to an adjacent or connected cell, and serves as a specific template for its own replication in the cytoplasm. Seeding into the complex cytoplasmic milieu happens within hours, implying the existence of unknown factors that regulate this process....

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PMID: 39773263
DOI: 10.1186/s13024-024-00783-z

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