Article

Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease

2025-09-19

Abstract excerpt

<h4>Summary</h4> The seeding of α-Synuclein (αSyn) is a key driver of Lewy pathology propagation in Parkinson’s disease (PD) and forms the basis for recent diagnostic advances. However, it remains unclear how the structural and biochemical features of αSyn seeds dictate their propagation efficiency, capacity to induce Lewy body formation, and resulting cellular toxicity. Using genetic and idiopathic PD cell model...

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Literature Corpus work: 471c3644-26f9-5fd7-883d-6b953808868e
DOI: 10.1101/2025.09.17.676873

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