Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.

doi:10.1016/j.cell.2024.03.015

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Article

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.

Cell - 9 May 2024

Parra Bravo Celeste, Giani Alice Maria, Madero-Perez Jesus, Zhao Zeping, Wan Yuansong, Samelson Avi J, Wong Man Ying, Evangelisti Alessandro, Cordes Ethan, Fan Li, Ye Pearly, Zhu Daphne, Pozner Tatyana, Mercedes Maria, Patel Tark, Yarahmady Allan, Carling Gillian K, Sterky Fredrik H, Lee Virginia M Y, Lee Edward B, DeTure Michael, Dickson Dennis W, Sharma Manu, Mok Sue-Ann, Luo Wenjie, Zhao Mingrui, Kampmann Martin, Gong Shiaoching, Gan Li

Abstract excerpt

Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to a lack of appropriate human models. Here, we engineered human induced pluripotent stem cell (hiPSC)-derived neuronal lines to express 4R Tau and 4R Tau carrying the P301S MAPT mutation when differentiated into neurons. 4R-P301S neurons display progressive Tau inclusions upon seeding with Tau...

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PMID: 38582079
DOI: 10.1016/j.cell.2024.03.015
PMCID: PMC11365117

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