Article

VCP increases or decreases tau seeding using specific cofactors

2023-09-01

Abstract excerpt

<h4>Background</h4> Neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to an adjacent or connected cell, and serves as a specific template for its own replication in the cytoplasm. In vitro seeding reactions typically take days, yet seeding into the complex cytoplasmic milieu can happen within hours. A cellular m...

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Identifiers and source

Literature Corpus work: 951c877c-b686-5832-8c2d-fba1b8a81c33
DOI: 10.1101/2023.08.30.555637

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