Article

VCP protects neurons from proteopathic seeding

2021-07-13

Abstract excerpt

<h4>SUMMARY</h4> Uptake and spread of proteopathic seeds, such as αS, Tau, and TDP-43, contribute to neurodegeneration. The cellular machinery necessary for this process is poorly understood. Using a genome-wide CRISPR-Cas9 screen, we identified Valosin Containing Protein (VCP) as a suppressor of αS seeding. Dominant mutations in VCP cause multisystem proteinopathy (MSP) with muscle and neuronal degeneration. VCP...

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Identifiers and source

Literature Corpus work: 3f1fe248-f952-570f-9152-d0cb2666be20
DOI: 10.1101/2021.07.12.452081

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