Article

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation

2023-06-22

Abstract excerpt

<h4>SUMMARY</h4> Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to lack of appropriate human models. Current human induced pluripotent stem cell (hiPSC)-derived neurons express very low levels of 4-repeat (4R)-tau isoforms that are normally expressed in adult brain. Here, we engineered new iPSC lines to express 4R-tau and 4R-tau carrying the...

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Literature Corpus work: 640fd862-a530-5839-8351-e375081880a9
DOI: 10.1101/2023.06.19.544278

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