Article
VCP suppresses proteopathic seeding in neurons.
Molecular neurodegeneration - 12 Apr 2022
Zhu Jiang, Pittman Sara, Dhavale Dhruva, French Rachel, Patterson Jessica N, Kaleelurrrahuman Mohamed Salman, Sun Yuanzi, Vaquer-Alicea Jaime, Maggiore Gianna, Clemen Christoph S, Buscher William J, Bieschke Jan, Kotzbauer Paul, Ayala Yuna, Diamond Marc I, Davis Albert A, Weihl Conrad
Abstract excerpt
BACKGROUND: Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), Tau, and TDP-43, contribute to neurodegeneration. The cellular machinery participating in this process is poorly understood. One proteinopathy called multisystem proteinopathy (MSP) is associated with dominant mutations in Valosin Containing Protein (VCP). MSP patients have muscle and neuronal degeneration...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.