Article

Seeded aggregation of ANXA11 induces prion-like propagation, TDP-43 co-pathology and nucleocytoplasmic transport defects

2026-03-26

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in ANXA11 cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet the mechanisms linking ANXA11 dysfunction to neurodegeneration remain poorly defined. Recent cryo-EM studies revealed heteromeric ANXA11-TDP-43 filaments in patient brains, suggesting a direct pathological connection between these two ALS-associated proteins. However, whether ANXA11 possesses int...

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Literature Corpus work: adc073bf-b868-5e50-86f5-d35433d8f87b
DOI: 10.64898/2026.03.24.713853

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