Article

Tau seeds translocate across the cell membrane to initiate aggregation

2022-05-12

Abstract excerpt

<h4>ABSTRACT</h4> Neurodegenerative tauopathies, including Alzheimer’s disease and related disorders, are caused by intracellular aggregation of tau protein in ordered assemblies. Experimental evidence suggests that tau assemblies propagate pathology across brain networks. Tau seeds enter cells through endocytosis but must access the cytoplasm to serve as templates for their own replication. The mechanism by whic...

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Literature Corpus work: 7ea15e5e-8984-5ed3-a9b0-4f618e78f830
DOI: 10.1101/2022.05.10.491429

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