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VCP Protects Neurons from Proteopathic Seeding

2021-08-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), tau, and TDP-43, contribute to neurodegeneration and disease progression. The cellular machinery necessary for this process is poorly understood. <bold>Methods: </bold>Cas9 expressing αS FRET biosensors were transduced with a whole-genome guide RNA (gRNA) library, seeded w...

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Literature Corpus work
bc91f031-5cc1-5992-8084-93d8b105ab9f
DOI
10.21203/rs.3.rs-786553/v1
Open publication

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VCP Protects Neurons from Proteopathic SeedingDOI 10.21203/rs.3.rs-786553/v1
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