Article

Computing the inducibility of B cell lineages under a context-dependent model of affinity maturation: Applications to sequential vaccine design

2023-10-17

Abstract excerpt

A key challenge in B cell lineage-based vaccine design is understanding the inducibility of target neutralizing antibodies. We approach this problem through the use of detailed stochastic modeling of the somatic hypermutation process that occurs during affinity maturation. Under such a model, sequence mutation rates are context-dependent , rendering standard probability calculations for sequence evolution intrac...

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Literature Corpus work: be96cba5-1fc0-52ae-9472-9db596ab21f4
DOI: 10.1101/2023.10.13.562156

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