Article

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody Development

2018-02-09

Abstract excerpt

<h4>SUMMARY</h4> HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced cytidine deaminase (AID) catalyzed somatic mutations for optimal neutralization potency. Probable mutations occur at sites of frequent AID activity, while improbable mutations occur where AID activity is infrequent. One bottleneck for induction of bnAbs is the evolution of viral envelopes (Envs) that can selec...

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Literature Corpus work: 9a54b634-1bf4-5944-8839-6238d3ea0720
DOI: 10.1101/262592

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