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Article

Minimal framework for optimizing vaccination protocols targeting highly mutable pathogens.

Physical review. E - 1 Dec 2024

Mahdisoltani Saeed, Murugan Pranav, Chakraborty Arup K, Kardar Mehran

Abstract excerpt

A persistent public health challenge is identifying immunization schemes that are effective against highly mutable pathogens such as HIV and influenza viruses. To address this, we analyze a simplified model of affinity maturation, the Darwinian evolutionary process B cells undergo during immunization. The vaccination protocol determines the selection forces that steer affinity maturation to generate antibodies....

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Identifiers

PMID: 39916243
DOI: 10.1103/PhysRevE.110.064137
PMCID: PMC12797877

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