Article

Antigen affinity and site of immunization dictate B cell recall responses

2024-04-23

Abstract excerpt

<h4>Summary</h4> Protective antibodies against HIV-1 require unusually high levels of somatic hypermutations (SHMs) introduced in germinal centers (GCs). To achieve this, a sequential vaccination approach was proposed. Using HIV-1 antibody knock-in mice with fate-mapping genes, we examined if antigen affinity affects the outcome of the B cell recall response. Compared to high affinity boost, low affinity boost re...

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Literature Corpus work: 03990f02-bef4-51a2-863e-3175403a05b4
DOI: 10.1101/2024.04.19.590239

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